Improving Sepsis Outcomes with ACESO


Known by it’s acronym, ACESO, the Austere environments Consortium for Enhanced Sepsis Outcomes is specifically focused on developing solutions to guide clinical decision-making in settings where a modern intensive care unit (ICU) is not available, including military deployments to areas with long medical evacuation chains, medical centers in low- and middle-income countries, and pandemic or other public health emergency settings.

Founded in 2010, ACESO is a consortium consisting of U.S. Government, non-profit, academic and industry partners administered by HJF and supported by overseas sites by HJFMRI.

ACESO’s efforts seek to provide a continuum in management of severe infections, leading with translational biology and bridging to diagnostics and adaptive clinical care with global application in any resource-limited setting. ACESO currently uses a combination of targeted laboratory testing platforms to identify candidate biomarkers of sepsis. Host-response patterns are then identified to characterize subgroups of patients in terms of mortality risk, infection type, and predicted treatment response profile.

Clinical Capabilities

ACESO’s efforts in strengthening clinical capabilities in resource-limited settings provides the platform to conduct regulated clinical trials for diagnostics and therapeutics. As part of this, ACESO is ensuring operational logistics in austere settings globally including training personnel, securing supply chain and mobile deployment, and maintaining compliant clinical data capture systems.